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KMID : 1189420180310010032
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Journal of Korean Oriental Medical Ophthalmology & Otolaryngology & Dermatology
2018 Volume.31 No. 1 p.32 ~ p.41
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An Experimental Study on the Effect of Angelica gigas Ethanol Extract on Hyaluronic Acid Synthesis
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Park Hye-Su
Ha Hun-Yong
Kim Hee-Taek
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Abstract
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Objectives : Hyaluronic acid(HA) is a mucopolysaccharide, occuring naturally in living organisms. It is one of the most hydrophilic molecules, so it has been known as being related to skin hydration and skin aging. The purpose of this study is to examine the effects of Angelica gigas(A. gigas) ethanol extract on hyaluronic acid synthesis.
Methods : To determine cytotoxicity and hyaluronic acid synthase 2 gene expression, hyaluronic acid production in HaCaT cells, MTT assay and RT-PCR ELISA was used.
Results : There were no cytotoxicity in 50㎍/㎖ concentration A. gigas extract in MTT assay. Hyaluronic acid synthase 2(HAS2) gene expression was increased by all treated concentration A. gigas extract. Hyaluronic acid production was higher than control group in 50㎍/㎖ & 100㎍/㎖ concentration A. gigas extract.
Conclusions : Hyaluronic acid production was increased by A. gigas extracts. Therefore, We suggest that A. gigas can make a contribution to the moisturizing effect on human skin.
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KEYWORD
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Angelica gigas, Hyaluronic acid, Hyaluronic acid synthesis, Moisturizing effect, HAS2
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